Alternatives for Span-assassin

Hello fellas, i would like to know if i am the only one that has spam issue on server.

i have customer that receive 250 spam/day

yes, spf, drbls lists enable, dkim, spam assassin , blacklist (2k domains blocked), list of IPs blocked.

I set spam assassin filter 2 per email account and still getting a lot of msg...
yes, spam assassin is runing...

i dont know what to do to block them.

i am using this:

DomainKeys spam protection: Verify incoming mail [] (unchecked - because there is too...

Alternatives for Span-assassin